Karen White, 52, was described as a “predator” who was a danger to women and children, Leeds Crown Court heard.
White, who was born male but now identifies as a woman and is transitioning, was jailed for two counts of rape, two sexual assaults and one offense of wounding.
The court heard she used her “transgender persona” to put herself in contact with vulnerable women.
She must serve a minimum term of nine-and-a-half years before parole can be considered.
White appeared by video link from HMP Leeds, and sat impassive during the hearing, wearing a patterned blouse and glasses with shoulder-length blond hair.
She attacked two women while at HMP New Hall, a women’s prison between September and October last year. At the time she was on remand for other offenses.
White also had previous convictions for indecent assault, indecent exposure and gross indecency involving children, violence and dishonesty.
Passing sentence Judge Christopher Batty told the defendant: “You are a predator and highly manipulative and in my view you are a danger.
“You represent a significant risk of serious harm to children, to women and to the general public.”
Christopher Dunn, prosecuting, told the court: “She is allegedly a transgender female.
“The prosecution say allegedly because there’s smatterings of evidence in this case that the defendant’s approach to transitioning has been less than committed.